Comparison of the Ames assay and the induction of sister chromatid exchanges: Results with ten pharmaceuticals and five selected agents
Identifieur interne : 003439 ( Main/Exploration ); précédent : 003438; suivant : 003440Comparison of the Ames assay and the induction of sister chromatid exchanges: Results with ten pharmaceuticals and five selected agents
Auteurs : Esmail K. Shubber [Iraq] ; David Jacobson-Kram [États-Unis] ; Jerry R. Williams [États-Unis]Source :
- Cell Biology and Toxicology [ 0742-2091 ] ; 1986-09-01.
English descriptors
- KwdEn :
- Teeft :
- Ames, Ames assay, Ames strains, Ames test, Amoscanate, Animal carcinogen, Annual meeting, Anthelmintic drugs, Antiamoebic drug, Antimalarial drug, Antimalarial drugs, Antischistosomal, Antischistosomal drug, Antischistosomal drugs, Assay, Azide, Bacterial culture, Bromide, Bueding, Carcinogen, Cell biology, Cell cultures, Cell lines, Cellular progression, Chinese hamster ovary, Chloroquine, Chloroquine diphosphate, Chromatid, Chromosomal damage, Colony formation, Crystal violet, Culture medium, Cultured cells, Dimethyl sulfoxide, Disease control, Drug exposure, Endpoint, Environmental mutagen society, Ethidium bromide, Fetal calf serum, Final concentration, Genetic toxicity, Genotoxic activity, Hamster, High potency, Human beings, Human cells, Human populations, Hycanthone, Induction, Intercalating agents, Johns hopkins university, Laboratory animals, Liver microsomes, Lucanthone, Mammalian cells, Metabolic activation, Mouse lymphoma cells, Mutagen, Mutagenic, Mutagenic activity, Mutagenicity, Mutagenicity studies, Mutagenicity tests, Mutat, Mutation, National institutes, Negative results, Niridazole, Oltipraz, Oxaminiquine, Personal communication, Pharmaceutical agents, Positive results, Praziquantel, Primaquine, Qualitative results, Quantitative data, Rodent cells, Salmonella, Salmonella strains, Salmonella typhimurium, Schistosoma mansoni, Schistosomiasis treatment, Shubber, Sister chromatid exchange, Sister chromatid exchanges, Sodium azide, Test system, Test systems, Tester, Tester strains, Toxicity, Toxicology, Typhimurium.
Abstract
: Seven antischistosomal drugs, two antimalarial drugs, and one antiamoebic drug were tested in all five Ames strains for induction of mutation, as well as for induction of cytotoxicity, inhibition of cellular progression, and the induction of sister chromatid exchanges in two cultured mammalian cell lines. We found that two agents shown to be negative in the Ames test were positive for sister chromatid exchange induction. Based on qualitative and quantitative evaluation, we find that all but three of the pharmaceuticals should be considered to be potential human carcinogens.
Url:
DOI: 10.1007/BF00121853
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000846
- to stream Istex, to step Curation: 000846
- to stream Istex, to step Checkpoint: 002198
- to stream Main, to step Merge: 003512
- to stream Main, to step Curation: 003439
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of the Ames assay and the induction of sister chromatid exchanges: Results with ten pharmaceuticals and five selected agents</title><author><name sortKey="Shubber, Esmail K" sort="Shubber, Esmail K" uniqKey="Shubber E" first="Esmail K." last="Shubber">Esmail K. Shubber</name></author><author><name sortKey="Jacobson Kram, David" sort="Jacobson Kram, David" uniqKey="Jacobson Kram D" first="David" last="Jacobson-Kram">David Jacobson-Kram</name></author><author><name sortKey="Williams, Jerry R" sort="Williams, Jerry R" uniqKey="Williams J" first="Jerry R." last="Williams">Jerry R. Williams</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9CCD52450D6D2B31713B80FB2DEFD6C6EFE7855F</idno><date when="1986" year="1986">1986</date><idno type="doi">10.1007/BF00121853</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-LQPQJX23-R/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000846</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000846</idno><idno type="wicri:Area/Istex/Curation">000846</idno><idno type="wicri:Area/Istex/Checkpoint">002198</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002198</idno><idno type="wicri:doubleKey">0742-2091:1986:Shubber E:comparison:of:the</idno><idno type="wicri:Area/Main/Merge">003512</idno><idno type="wicri:Area/Main/Curation">003439</idno><idno type="wicri:Area/Main/Exploration">003439</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Comparison of the Ames assay and the induction of sister chromatid exchanges: Results with ten pharmaceuticals and five selected agents</title><author><name sortKey="Shubber, Esmail K" sort="Shubber, Esmail K" uniqKey="Shubber E" first="Esmail K." last="Shubber">Esmail K. Shubber</name><affiliation wicri:level="1"><country xml:lang="fr">Iraq</country><wicri:regionArea>Department of Biology, College of Science, University of Baghdad, Baghdad</wicri:regionArea><wicri:noRegion>Baghdad</wicri:noRegion></affiliation></author><author><name sortKey="Jacobson Kram, David" sort="Jacobson Kram, David" uniqKey="Jacobson Kram D" first="David" last="Jacobson-Kram">David Jacobson-Kram</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Radiobiology Laboratory, The Johns Hopkins Oncology Center, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Williams, Jerry R" sort="Williams, Jerry R" uniqKey="Williams J" first="Jerry R." last="Williams">Jerry R. Williams</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Radiobiology Laboratory, The Johns Hopkins Oncology Center, Baltimore</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell Biology and Toxicology</title><title level="j" type="abbrev">Cell Biol Toxicol</title><idno type="ISSN">0742-2091</idno><idno type="eISSN">1573-6822</idno><imprint><publisher>Kluwer Academic Publishers</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="1986-09-01">1986-09-01</date><biblScope unit="volume">2</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="379">379</biblScope><biblScope unit="page" to="399">399</biblScope></imprint><idno type="ISSN">0742-2091</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0742-2091</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ames assay</term><term>antiamoebic drug</term><term>antimalarial drug</term><term>antischistosomal drug</term><term>mutagen screening</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Ames</term><term>Ames assay</term><term>Ames strains</term><term>Ames test</term><term>Amoscanate</term><term>Animal carcinogen</term><term>Annual meeting</term><term>Anthelmintic drugs</term><term>Antiamoebic drug</term><term>Antimalarial drug</term><term>Antimalarial drugs</term><term>Antischistosomal</term><term>Antischistosomal drug</term><term>Antischistosomal drugs</term><term>Assay</term><term>Azide</term><term>Bacterial culture</term><term>Bromide</term><term>Bueding</term><term>Carcinogen</term><term>Cell biology</term><term>Cell cultures</term><term>Cell lines</term><term>Cellular progression</term><term>Chinese hamster ovary</term><term>Chloroquine</term><term>Chloroquine diphosphate</term><term>Chromatid</term><term>Chromosomal damage</term><term>Colony formation</term><term>Crystal violet</term><term>Culture medium</term><term>Cultured cells</term><term>Dimethyl sulfoxide</term><term>Disease control</term><term>Drug exposure</term><term>Endpoint</term><term>Environmental mutagen society</term><term>Ethidium bromide</term><term>Fetal calf serum</term><term>Final concentration</term><term>Genetic toxicity</term><term>Genotoxic activity</term><term>Hamster</term><term>High potency</term><term>Human beings</term><term>Human cells</term><term>Human populations</term><term>Hycanthone</term><term>Induction</term><term>Intercalating agents</term><term>Johns hopkins university</term><term>Laboratory animals</term><term>Liver microsomes</term><term>Lucanthone</term><term>Mammalian cells</term><term>Metabolic activation</term><term>Mouse lymphoma cells</term><term>Mutagen</term><term>Mutagenic</term><term>Mutagenic activity</term><term>Mutagenicity</term><term>Mutagenicity studies</term><term>Mutagenicity tests</term><term>Mutat</term><term>Mutation</term><term>National institutes</term><term>Negative results</term><term>Niridazole</term><term>Oltipraz</term><term>Oxaminiquine</term><term>Personal communication</term><term>Pharmaceutical agents</term><term>Positive results</term><term>Praziquantel</term><term>Primaquine</term><term>Qualitative results</term><term>Quantitative data</term><term>Rodent cells</term><term>Salmonella</term><term>Salmonella strains</term><term>Salmonella typhimurium</term><term>Schistosoma mansoni</term><term>Schistosomiasis treatment</term><term>Shubber</term><term>Sister chromatid exchange</term><term>Sister chromatid exchanges</term><term>Sodium azide</term><term>Test system</term><term>Test systems</term><term>Tester</term><term>Tester strains</term><term>Toxicity</term><term>Toxicology</term><term>Typhimurium</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">: Seven antischistosomal drugs, two antimalarial drugs, and one antiamoebic drug were tested in all five Ames strains for induction of mutation, as well as for induction of cytotoxicity, inhibition of cellular progression, and the induction of sister chromatid exchanges in two cultured mammalian cell lines. We found that two agents shown to be negative in the Ames test were positive for sister chromatid exchange induction. Based on qualitative and quantitative evaluation, we find that all but three of the pharmaceuticals should be considered to be potential human carcinogens.</div></front></TEI><affiliations><list><country><li>Iraq</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="Iraq"><noRegion><name sortKey="Shubber, Esmail K" sort="Shubber, Esmail K" uniqKey="Shubber E" first="Esmail K." last="Shubber">Esmail K. Shubber</name></noRegion></country><country name="États-Unis"><region name="Maryland"><name sortKey="Jacobson Kram, David" sort="Jacobson Kram, David" uniqKey="Jacobson Kram D" first="David" last="Jacobson-Kram">David Jacobson-Kram</name></region><name sortKey="Williams, Jerry R" sort="Williams, Jerry R" uniqKey="Williams J" first="Jerry R." last="Williams">Jerry R. Williams</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003439 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003439 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:9CCD52450D6D2B31713B80FB2DEFD6C6EFE7855F
|texte= Comparison of the Ames assay and the induction of sister chromatid exchanges: Results with ten pharmaceuticals and five selected agents
}}
| This area was generated with Dilib version V0.6.33. |  |